Furan → 2-Heptanoylfuran

Temperatur

50 °C

In 50 ml of toluene were dissolved 6.51 g (0.05 mole) of heptanoic acid, 4.43 g (0.065 mole) of furan and 14.39 g (0.06 mole) of dichloroacetic anhydride. To the resulting solution was added 0.71 g of boron trifluoridediethyl ether coplex and the resulting mixture was then stirred at 50° C. for 3 hours. After completion of the reaction, the reaction solution was cooled and washed successively with 5% aqueous sodium carbonate solution and water. The organic layer was concentrated under reduced pressure and the resulting concentrated residue was then purified by silica gel-filled column chromatography to obtain 8.95 g of 2-heptanoylfuran.

1. customAfter completion of the reaction
2. temperaturethe reaction solution was cooled
3. washwashed successively with 5% aqueous sodium carbonate solution and water
4. concentrationThe organic layer was concentrated under reduced pressure
5. customthe resulting concentrated residue was then purified by silica gel-
6. additionfilled column chromatography

ORD-Eintrag

ord-218971747ed74ae7872997c922fec91f

Quelldatensatz

uspto-grants-1989_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04812585