1-(triphenylmethyl)-1H-imidazole-4-carbaldehyde → alpha-(4H-1,3-Benzodioxin-6-yl)-1-triphenylmethyl-1H-imidazole-4-methanol

HRID 1194370

Reaktionsgleichung

Reaktionsgleichung von HRID 1194370
Br[C:2]1[CH:11]=[CH:10][C:5]2[O:6][CH2:7][O:8][CH2:9][C:4]=2[CH:3]=1.[C:12]1([C:18]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:19]2[CH:23]=[C:22]([CH:24]=[O:25])[N:21]=[CH:20]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[O:6]1[C:5]2[CH:10]=[CH:11][C:2]([CH:24]([C:22]3[N:21]=[CH:20][N:19]([C:18]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)([C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)[C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[CH:23]=3)[OH:25])=[CH:3][C:4]=2[CH2:9][O:8][CH2:7]1

Komponenten

3

Edukt 2

HCID 6182331-(triphenylmethyl)-1H-imidazole-4-carbaldehydeHCID 145203376-Bromo-4H-1,3-benzodioxine

Produkt 1

HCID 14520344alpha-(4H-1,3-Benzodioxin-6-yl)-1-triphenylmethyl-1H-imidazole-4-methanolAusbeute 53 %

Versuchsvorschrift

This compound is prepared like the preceding compound but starting from 6-bromo-4H-1,3-benzodioxin and 1-triphenylmethyl-1H-imidazole-4-carboxaldehyde. After decomposing the reaction mixture, the reaction product is extracted with dichloromethane and recrystallized from isopropyl alcohol. By chromatography of the residue obtained after evaporation of the mother liquors, there is obtained a second crop of product. Yield: 53% of theory; M.P.: 165°-167° C.

Aufarbeitung

  1. customThis compound is prepared like the preceding compound
  2. extractionthe reaction product is extracted with dichloromethane
  3. customrecrystallized from isopropyl alcohol
  4. customBy chromatography of the residue obtained
  5. customafter evaporation of the mother liquors
  6. customthere is obtained a second crop of product

Quellen und Nachweise

ORD-Eintrag
ord-8522ab1a0ab442ca861b3c58720b5f57
Quelldatensatz
uspto-grants-1989_03
Patentnummer
US04814343

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