Thionyl Chloride → (S)-(-)-(3-Chloro-2-hydroxypropyl)trimethylammonium chloride

Temperatur

100 °C

Moreover, the obtained (S)-2,3-dihydroxypropyltrimethylammonium chloride was suspended in 100 ml of dimethylformamide and then 22.57 g of thionyl chloride was added thereto at a tempareture from 5° to 10° C. After stirring for 20 minutes, it was heated for 5 hours at 100° C. Finally, after the reaction was completed and the reaction mixture was cooled to room temperature, it was evaporated to dryness and then the residue was washed with methylene chloride to give 30.20 g of (S)-3-chloro-2-hydroxypropyltrimethylammonium chloride.

1. customfrom 5° to 10° C
2. temperaturethe reaction mixture was cooled to room temperature
3. customit was evaporated to dryness
4. washthe residue was washed with methylene chloride

ORD-Eintrag

ord-501095971757421a9354fc5a6bdb2e74

Quelldatensatz

uspto-grants-1989_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04814506