Ici 109,081 → 6-(4-(3-tert.-Butoxycarbonyl-thiazolidin-2-yl-carbonyl-amino)-phenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone
Reaktionsgleichung
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][S:10][CH:9]1[C:13]([OH:15])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]([CH3:30])[CH2:25][C:26](=[O:29])[NH:27][N:28]=2)=[CH:19][CH:18]=1>O1CCCC1>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][S:10][CH:9]1[C:13]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]([CH3:30])[CH2:25][C:26](=[O:29])[NH:27][N:28]=2)=[CH:19][CH:18]=1)=[O:15])=[O:7])([CH3:2])([CH3:3])[CH3:4]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
7.5 g (0.032 mole) of 3-tert.-butoxycarbonyl-thiazolidine-2-carboxylic acid and 5.2 g (0.032 mole) of N,N'-carbonyl-diimidazole are heated under reflux in 50 ml of tetrahydrofuran for 15 minutes. After addition of 6.1 g (0.03 mole) of 6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone, the mixture is stirred at room temperature for 18 hours and concentrated and the residue is crystallised with ethyl acetate.