Hydrochloric Acid → HCID 12300190, Verbindung

HRID 1195075Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1195075
[OH-].[K+].C[O:4][C:5]([C@@H:7]1[CH:22]=[C:21]2[C@@H:11]([CH2:12][C:13]3[C:23]4[C:16](=[CH:17][CH:18]=[CH:19][C:20]2=4)[NH:15][C:14]=3[Br:24])[N:9]([CH3:10])[CH2:8]1)=[O:6].Cl>C(O)C>[Br:24][C:14]1[NH:15][C:16]2[C:23]3[C:13]=1[CH2:12][C@@H:11]1[C:21]([C:20]=3[CH:19]=[CH:18][CH:17]=2)=[CH:22][C@@H:7]([C:5](=[O:4])[OH:6])[CH2:8][N:9]1[CH3:10]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13059865HCID 13059865, Verbindung

Produkt 1

HCID 12300190HCID 12300190, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

20 ml of 20% aqueous potassium hydroxide solution are added to the solution of 1 g of 2-bromolysergic acid methyl ester in 6 ml of ethanol, then the solution is stirred in a bath of 80° C. for one hour. The pH value of the solution cooled down is adjusted to 7 by adding aqueous hydrochloric acid. The crystalline precipitate obtained on cooling is filtered off, washed with water and dried to give the title compound in a yield of 0.5 g (0.0014 mole, 50%).

Aufarbeitung

  1. temperatureThe pH value of the solution cooled down
  2. customThe crystalline precipitate obtained
  3. temperatureon cooling
  4. filtrationis filtered off
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a1fd274d04e24daabc96a64d1c3208c1
Quelldatensatz
uspto-grants-1989_03
Patentnummer
US04816587

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