Benzyl Bromide → 7,8-Dihydro-2-(phenylmethoxy)-5(6H)-quinolinone

HRID 1195156Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1195156
[O:1]=[C:2]1[CH2:11][CH2:10][CH2:9][C:8]2[NH:7][C:6](=[O:12])[CH:5]=[CH:4][C:3]1=2.[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(=O)([O-])[O-].[Ag+2].C1(C)C=CC=CC=1>[O:1]=[C:2]1[CH2:11][CH2:10][CH2:9][C:8]2[N:7]=[C:6]([O:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:5]=[CH:4][C:3]1=2

Komponenten

5

Edukt 2

HCID 7498Benzyl BromideHCID 2674502-Hydroxy-7,8-dihydro-5(6H)-quinolinone

Produkt 1

HCID 104449777,8-Dihydro-2-(phenylmethoxy)-5(6H)-quinolinoneAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418647HCID 178418647, VerbindungKatalysatorHCID 1140TolueneLösungsmittel

Versuchsvorschrift

A suspension of 5,6,7,8-tetrahydro-5-oxo-2(1H)-quinolinone (33.0 g), silver carbonate (35.0 g), benzyl bromide (44.4 g), and toluene (400 ml) was stirred at room temperature for 72 hrs. The mixture was filtered and the filtrate was concentrated. Trituration of the residue with petroleum ether gave 45.6 g (83%) of product.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-1fb314b3916f4c5d9f0ec74a4d9462d1
Quelldatensatz
uspto-grants-1992_05
Patentnummer
US05110815

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