Hydrochloric Acid → Methyl L-lysinate dihydrochloride

HRID 1196151

Reaktionsgleichung

Reaktionsgleichung von HRID 1196151
N[C@H:2](C(O)=O)CC1C=CC=CC=1.[ClH:13].[NH2:14][C@H:15]([C:21]([OH:23])=[O:22])[CH2:16][CH2:17][CH2:18][CH2:19][NH2:20].Cl>CO>[ClH:13].[ClH:13].[CH3:2][O:22][C:21](=[O:23])[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[NH2:14]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6140L-PhenylalanineHCID 69568L-Lysine monohydrochloride

Produkt 1

HCID 117778Methyl L-lysinate dihydrochlorideAusbeute 81,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The same esterification procedure as in Example 1 was followed with the exception that the L-phenylalanine was replaced with 182.6 g of L-lysine hydrochloride and that 182.6 g of methanol and 87.3 g of hydrochloric acid were used. Following cooling in order to deposit the crystals, the latter were collected by filtration and then dried to obtain 196.2 g (81.3% yield) of L-lysine methyl ester dihydrochloride having a purity of 96.6% and containing 0.2% of water and 1.3% of L-lysine hydrochloride.

Aufarbeitung

  1. temperatureFollowing cooling in order
  2. filtrationthe latter were collected by filtration
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a684a2a53a82466280c15e3ac7fb6c5f
Quelldatensatz
uspto-grants-1992_05
Patentnummer
US05113009

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