Thionyl Chloride → 4-(4-Trifluoromethylbenzyloxy)-2-chloromethylpyridine

HRID 1196623Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1196623
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:18]=[CH:17][C:6]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([CH2:15]O)[CH:10]=2)=[CH:5][CH:4]=1.S(Cl)([Cl:23])=O>ClCCl>[F:1][C:2]([F:20])([F:19])[C:3]1[CH:18]=[CH:17][C:6]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([CH2:15][Cl:23])[CH:10]=2)=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 144259724-(4-Trifluoromethylbenzyloxy)-2-hydroxymethylpyridine

Produkt 1

HCID 144259864-(4-Trifluoromethylbenzyloxy)-2-chloromethylpyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

2.2 g (7.8 mmol) of the title compound from Example 3 are dissolved in 50 ml of anhydrous dichloromethane and a solution of 2 ml of thionyl chloride in 6 ml of dichloromethane is added dropwise at -10° C. The mixture is warmed to room temperature, stirred for 30 minutes more, and concentrated. The crystalline residue is brought to crystallization using diisopropyl ether and dried using an oilpump, m.p. 133°-135° C.

Aufarbeitung

  1. concentrationconcentrated
  2. customThe crystalline residue is brought to crystallization
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a9a3fc14b80044d4ada986a19f0862a4
Quelldatensatz
uspto-grants-1992_05
Patentnummer
US05114955

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