4-(4-Trifluoromethylbenzyloxy)-2-chloromethylpyridine → 2-[4-(4-Trifluoromethylbenzyloxy)-2-picolylmercapto]-1H-thieno[3,4-d]imidazole dihydrochloride

HRID 1196624Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1196624
[SH:1][C:2]1[NH:3][C:4]2[C:5](=[CH:7][S:8][CH:9]=2)[N:6]=1.[F:10][C:11]([F:29])([F:28])[C:12]1[CH:27]=[CH:26][C:15]([CH2:16][O:17][C:18]2[CH:23]=[CH:22][N:21]=[C:20]([CH2:24][Cl:25])[CH:19]=2)=[CH:14][CH:13]=1>C(O)C>[ClH:25].[ClH:25].[F:29][C:11]([F:10])([F:28])[C:12]1[CH:27]=[CH:26][C:15]([CH2:16][O:17][C:18]2[CH:23]=[CH:22][N:21]=[C:20]([CH2:24][S:1][C:2]3[NH:6][C:5]4=[CH:7][S:8][CH:9]=[C:4]4[N:3]=3)[CH:19]=2)=[CH:14][CH:13]=1

Komponenten

4

Edukt 2

HCID 144259864-(4-Trifluoromethylbenzyloxy)-2-chloromethylpyridineHCID 178527818HCID 178527818, Verbindung

Produkt 1

HCID 198989772-[4-(4-Trifluoromethylbenzyloxy)-2-picolylmercapto]-1H-thieno[3,4-d]imidazole dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

0.625 g (4 mmol) of 2-mercaptothieno[3,4-d]imidazole are added at 25° C. to 1.35 g (4 mmol) of the title compound from Example 4 in 50 ml of ethanol, and the mixture is stirred at 60° C. for 1.5 hours. The reaction mixture is concentrated in vacuo, and the residue is treated with acetone, filtered off with suction, washed with acetone and dried in vacuo, m.p. 180°-182° C.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. additionthe residue is treated with acetone
  3. filtrationfiltered off with suction
  4. washwashed with acetone
  5. customdried in vacuo, m.p. 180°-182° C.

Quellen und Nachweise

ORD-Eintrag
ord-b3d8160494eb43e98587a971b3517321
Quelldatensatz
uspto-grants-1992_05
Patentnummer
US05114955

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