Dimethylamine → (3-(Dimethylamino)propyl)triphenylphosphonium bromide hydrobromide

HRID 1196987Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1196987
[BrH:1].[Br-].[Br:3][CH2:4][CH2:5][CH2:6][P+:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH3:26][NH:27][CH3:28]>C(O)C>[BrH:3].[Br-:1].[CH3:26][N:27]([CH3:28])[CH2:4][CH2:5][CH2:6][P+:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 19897085(3-Bromopropyl)-triphenylphosphonium bromide hydrobromide

Produkt 1

HCID 23651404(3-(Dimethylamino)propyl)triphenylphosphonium bromide hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Then, 100.0 g of (3-bromopropyl)-triphenylphosphonium bromide hydrobromide is suspended in 500 ml of ethanol and 300 ml of 50% aqueous dimethylamine solution is added thereto. After heating the mixture at reflux for 10 minutes, the mixture is allowed to stand for cooling. The solvent is distilled away under reduced pressure and the resultant crude product is recrystallized from ethanol to obtain 64.0 g of the desired product having the physicochemical properties as identified in Table 8.

Aufarbeitung

  1. temperatureAfter heating the mixture
  2. temperatureat reflux for 10 minutes
  3. temperaturefor cooling
  4. distillationThe solvent is distilled away under reduced pressure
  5. customthe resultant crude product is recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-a8437e3468174024ae8d418037873a05
Quelldatensatz
uspto-grants-1992_05
Patentnummer
US05116863

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