4-Bromophenol → 4-Bromo-2-fluorophenol

Temperatur

45 °C

A mixture of 0.86 g of 4-bromophenol, 1.67 g of N-fluoro-2-chloro-6-(trichloromethyl)pyridinium fluoroborate, and 40 ml of 1,1,2-trichloroethane was placed in a 100 ml 3-necked round bottomed flask equipped with a magnetic stirring bar, a thermometer, and a reflux condenser. The mixture was heated to 45° C. and allowed to react at that temperature for 23 hours under nitrogen. The mixture was then allowed to cool. Analysis by standardized gas-liquid chromatography using a mass spectrometer detector indicated that the title product was present in 74 percent conversion. The product identity was confirmed by its known 19F and 1H NMR spectra.

1. customwas placed in a 100 ml 3-necked round bottomed flask
2. customequipped with a magnetic stirring bar
3. customto react at that temperature for 23 hours under nitrogen
4. temperatureto cool

ORD-Eintrag

ord-977018f7e36448daaa81fb7e1e754ecd

Quelldatensatz

uspto-grants-1992_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05116982