Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Acetamide | HCID 178 | — |
| Edukt | Potassium Fluoride | HCID 522689 | — |
| Edukt | methyl 6-benzoyloxy-2(RS)-bromohexanoate | HCID 15222235 | — |
| Produkt | methyl 6-benzoyloxy-2(RS)-fluorohexanoate | HCID 15224608 | — |
| Produkt | Methyl 6-benzoyloxyhexanoate | HCID 19930972 | 58,3% |
Reaktionsschritte
A mixture of methyl 6-benzoyloxy-2(RS)-bromohexanoate (e) (14.02 g), potassium fluoride (12.59 g) and acetamide (12.3 g) was stirred at 105° C. for 6 hours. The crude product obtained by treating in the conventional manner was subjected to silica gel chromatography to give the title compound (f) and methyl 6-benzoyloxyhexanoate (g) (3.11 g, yield: 29%). Yield: 5.28 g (46%)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US05117042 |
|---|
| Quelldatensatz | uspto-grants-1992_05 |
|---|
| ORD ID | ord-7c1c1f17e99e46ce86c0edbb36248acc |
|---|
| Quellennotiz | uspto-grants-1992_05 |
|---|
