Potassium Carbonate → HCID 178418677, Verbindung

HRID 1198322

Reaktionsgleichung

Reaktionsgleichung von HRID 1198322
[F:1][C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH:5]=[CH:4][C:3]=1[OH:14].[CH2:15]([C@H:20]1[CH2:25][CH2:24][C@H:23]([CH2:26]Br)[CH2:22][CH2:21]1)[CH2:16][CH2:17][CH2:18][CH3:19].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:10]([O:9][C:6]1[CH:5]=[CH:4][C:3]([O:14][CH2:26][C@H:23]2[CH2:24][CH2:25][C@H:20]([CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH2:21][CH2:22]2)=[C:2]([F:1])[C:7]=1[F:8])[CH2:11][CH2:12][CH3:13]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 191034334-Butoxy-2,3-difluorophenolHCID 178444389HCID 178444389, Verbindung

Produkt 1

HCID 178418677HCID 178418677, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

0.1 mol of 2,3-difluoro-4-butoxyphenol, 0.11 mol of trans-4-pentylcyclohexylmethyl bromide and 0.11 mol of potassium carbonate are heated at 100° in 100 ml of dimethylformamide (DMF) for 16 hours. After cooling, the inorganic salts are filtered off with suction, the filtrate is concentrated and water is added. Extraction with methylene chloride gives 1-butoxy-2,3-difluoro-4-(trans-4-pentylcyclohexylmethoxy)benzene.

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe inorganic salts are filtered off with suction
  3. concentrationthe filtrate is concentrated
  4. additionwater is added
  5. extractionExtraction with methylene chloride

Quellen und Nachweise

ORD-Eintrag
ord-1bae8b3220744c4abf0f5bfe7aab8377
Quelldatensatz
uspto-grants-1994_01
Patentnummer
US05279764

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