Nitric Acid → 4-(2-Nitrophenyl)butyronitrile
Reaktionsgleichung
[C:1]1([CH2:7][CH2:8][CH2:9][C:10]#[N:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N+:12]([O-])([OH:14])=[O:13]>>[N+:12]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=1[CH2:7][CH2:8][CH2:9][C:10]#[N:11])([O-:14])=[O:13]Komponenten
3
Versuchsvorschrift
4-Phenylbutyronitrile (12.7 g) was added dropwise to stirred concentrated nitric acid (55 ml) at 5°-10° C. and the mixture was stirred for 2 hours at 20°-25° C. The deep yellow solution was poured onto ice and extracted with dichloromethane. The extract was dried and evaporated and the residue was chromatographed on silica in ethyl acetate-hexane (1:4) to isolate the minor product.
Aufarbeitung
- additionThe deep yellow solution was poured onto ice
- extractionextracted with dichloromethane
- customThe extract was dried
- customevaporated
- customthe residue was chromatographed on silica in ethyl acetate-hexane (1:4)
- customto isolate the minor product
Quellen und Nachweise
- ORD-Eintrag
- ord-aa8b86666141487e8d6fcbc603644825
- Quelldatensatz
- uspto-grants-1994_01
- Patentnummer
- US05281593
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