HCID 85126173, Verbindung → HCID 15223491, Verbindung

HRID 1198610Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1198610
[CH2:1]([N:8]1[CH2:12][CH:11]([C:13](=[N:15]O)[CH3:14])[CH2:10][C:9]1=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>N.[Ni]>[NH2:15][CH:13]([CH:11]1[CH2:12][N:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9](=[O:17])[CH2:10]1)[CH3:14]

Komponenten

4

Edukt 1

HCID 85126173HCID 85126173, Verbindung

Produkt 1

HCID 15223491HCID 15223491, VerbindungAusbeute 91,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysator2×HCID 222AmmoniaLösungsmittel

Versuchsvorschrift

1-Benzyl-4-(1-hydroxyiminoethyl)-2-oxopyrrolidine (16.81 g, 0.072 mole), was hydrogenated in saturated methanolic ammonia (200 mL) at 50 psi and 25° with Raney nickel (5 g) for 23 hours. Additional Raney nickel (5 g) was added and hydrogenation continued for three hours. The reaction was Celite filtered and the solvent was removed under reduced pressure to give 4-(1-aminoethyl)-1-benzyl-2-oxopyrrolidine (14.4 g, 91%) as a brown oil which solidified on standing to a brown solid.

Aufarbeitung

  1. filtrationfiltered
  2. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f4031b5520b943d0a7d15cfddfdef667
Quelldatensatz
uspto-grants-1994_01
Patentnummer
US05281612

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