HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(Trifluoromethyl)phenylhydrazine → 5-n-Butyl-2,4-dihydro-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(Trifluoromethyl)phenylhydrazine | HCID 520800 | — |
| Edukt | ethyl N-carbethoxyvalerimidate | HCID 53930077 | — |
| Produkt | 5-n-Butyl-2,4-dihydro-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one | HCID 135527027 | 66% |
Reaktionsschritte
Ethyl-N-carbethoxyvalerimidate (from Example 3, Step B) was reacted with 2-(trifluoromethyl)phenylhydrazine according to the procedure of Example 3, Step C. Flash chromatography of the crude product on silica gel (gradient elution with 0.5-2% MeOH in CH2Cl2) gave a 66% yield of the title compound as white crystals, mp 124°-126° C.; homogeneous by TLC in 19:1 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 286 (M+1)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05281614 |
| Quelldatensatz | uspto-grants-1994_01 |
| ORD ID | ord-9c20c2ce9ae947c9b21655644db5a86d |
| Quellennotiz | uspto-grants-1994_01 |