Ammonia → 7-amino-2-(2-cyclohexylethyl)-6-nitro-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

HRID 1199104Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1199104
Cl[C:2]1[N:3]=[C:4]2[S:14][C:13]([CH2:15][CH2:16][CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)=[N:12][N:5]2[C:6](=[O:11])[C:7]=1[N+:8]([O-:10])=[O:9].[NH3:23]>C(O)C>[NH2:23][C:2]1[N:3]=[C:4]2[S:14][C:13]([CH2:15][CH2:16][CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)=[N:12][N:5]2[C:6](=[O:11])[C:7]=1[N+:8]([O-:10])=[O:9]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 103153767-chloro-2-(2-cyclohexylethyl)-6-nitro-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Produkt 1

HCID 100875627-amino-2-(2-cyclohexylethyl)-6-nitro-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In 100 ml of ethanol was suspended 9.59 g of 7-chloro-2-(2-cyclohexylethyl)-6-nitro-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, and 7 ml of concentrated aqueous ammonia was added thereto at room temperature while stirring. The stirring was continued for 5.5 hours. The precipitate formed was collected by filtration and washed successively with ethanol and diethyl ether to obtain 7.05 g of 7-amino-2-(2-cyclohexylethyl)-6-nitro-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one as a pale yellow crystal.

Aufarbeitung

  1. additionwas added
  2. customThe precipitate formed
  3. filtrationwas collected by filtration
  4. washwashed successively with ethanol and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-32492e2cc2574e199a0a767297e21d7d
Quelldatensatz
uspto-grants-1990_02
Patentnummer
US04898943

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