Reaktionsgleichung
[F:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7](=[O:9])[S:8][C:4]=2[CH:3]=1.S(=O)(=O)(O)O.[N+:17]([O-])([OH:19])=[O:18]>>[F:1][C:2]1[C:11]([N+:17]([O-:19])=[O:18])=[CH:10][C:5]2[NH:6][C:7](=[O:9])[S:8][C:4]=2[CH:3]=1Komponenten
4
Versuchsvorschrift
Explaining the above conversion, 6-fluoro-2(3H) -benzothiazolone (V) [G. Mazzone et al: Farmaco, Ed. Sc., 32, (5), 348 (1977)] is reacted with a nitrating agent such as a mixture of sulfuric acid and nitric acid to give 6-fluoro-5-nitro-2(3H)-benzothiazolone (VI). The reaction is accomplished at a temperature of -10° to 10° C. instantaneously or within 5 hours. Sulfuric acid and nitric acid are respectively used in amounts of one equivalent to an excess amount and of 1 to 1.2 equivalents to the compound (V).
Quellen und Nachweise
- ORD-Eintrag
- ord-56844ed35fe94acb9f51e9b70eeda0cf
- Quelldatensatz
- uspto-grants-1990_02
- Patentnummer
- US04898948
Verknüpfte Notizen
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