Methyl iodide → HCID 19866662, Verbindung

HRID 1199448Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1199448
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13]([C:15]1[NH:19][C:18]2[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=2[N:16]=1)=[O:14].CI.[C:26](=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:26][N:19]1[C:18]2[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=2[N:16]=[C:15]1[S:13]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[O:14]

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 219575582-[2-(2-Pyridyl)-phenyl sulphinyl]-1H-benzimidazole

Produkt 1

HCID 19866662HCID 19866662, VerbindungAusbeute 75,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2-[2-(2-Pyridyl)-phenyl sulphinyl]-1H-benzimidazole (Example 13) (0.7 g) in dry dimethylformamide (50 ml), methyl iodide (0.34 g) and anhydrous potassium carbonate (1.1 g) were stirred at room temperature for 1.75 hours. The mixture was poured onto water, extracted into ethyl acetate, washed, dried and evaporated under reduced pressure to leave the title compound as a cream solid (0.55 g).

Aufarbeitung

  1. additionThe mixture was poured onto water
  2. extractionextracted into ethyl acetate
  3. washwashed
  4. customdried
  5. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-07694a1e29374731b0c563de699b3429
Quelldatensatz
uspto-grants-1990_02
Patentnummer
US04900751

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