Potassium Carbonate → 5,6-Dimethoxy-2-(5-methoxy-2-nitrophenylthio)-1H-benzimidazole

HRID 1199460Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1199460
[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][C:6]2=[N:7][C:8](=[S:10])[N:9]=[C:5]2[CH:4]=1.Cl[C:16]1[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:17]=1[N+:24]([O-:26])=[O:25].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][C:6]2[NH:7][C:8]([S:10][C:16]3[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:17]=3[N+:24]([O-:26])=[O:25])=[N:9][C:5]=2[CH:4]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 5937892-Chloro-4-methoxy-1-nitrobenzeneHCID 149735355,6-Dimethoxy benzimidazole-2-thione

Produkt 1

HCID 198667335,6-Dimethoxy-2-(5-methoxy-2-nitrophenylthio)-1H-benzimidazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

5,6-Dimethoxy benzimidazole-2-thione (4.0 g), 2-chloro-4-methoxy nitrobenzene (3.6 g) and potassium carbonate (2.65 g) were stirred together in dry dimethyl formamide (30 ml) at 95° for 3 days. The cooled mixture was poured onto water (300 ml) and the precipitate collected. The solid was washed with water and dried to leave the sub-title compound as a pale yellow solid, MS 361 bp 207.

Aufarbeitung

  1. additionThe cooled mixture was poured onto water (300 ml)
  2. customthe precipitate collected
  3. washThe solid was washed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-474972a81f87497380aaf001ea0a06c6
Quelldatensatz
uspto-grants-1990_02
Patentnummer
US04900751

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