Methanol → 1-(3,5-Dichlorophenyl)-4-methoxycarbonyl-5-pyrazolecarboxamide

HRID 1199830

Reaktionsgleichung

Reaktionsgleichung von HRID 1199830
[C:1]([C:4]1[CH:5]=[N:6][N:7]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=2)[C:8]=1[C:9]([NH2:11])=[O:10])([OH:3])=[O:2].[CH3:20]O>>[Cl:19][C:14]1[CH:13]=[C:12]([N:7]2[C:8]([C:9]([NH2:11])=[O:10])=[C:4]([C:1]([O:3][CH3:20])=[O:2])[CH:5]=[N:6]2)[CH:17]=[C:16]([Cl:18])[CH:15]=1

Komponenten

3

Edukt 2

HCID 887MethanolHCID 1638961H-Pyrazole-4-carboxylic acid, 5-(aminocarbonyl)-1-(3,5-dichlorophenyl)-

Produkt 1

HCID 144213131-(3,5-Dichlorophenyl)-4-methoxycarbonyl-5-pyrazolecarboxamide

Versuchsvorschrift

A 1.5 g portion of the compound of Example 2 was suspended in 30 ml of methanol, and hydrogen chloride gas was bubbled through the suspension for 1 minute. Then 30 ml of methanol was added over a 5 minute period while the addition of gas was continued. Then the mixture was heated under reflux for 2 hours, and was cooled and filtered. The solids were collected and dried to obtain 1.15 g of the desired product, m.p. 220°-222°.

Aufarbeitung

  1. customhydrogen chloride gas was bubbled through the suspension for 1 minute
  2. additionThen 30 ml of methanol was added over a 5 minute period while the addition of gas
  3. temperatureThen the mixture was heated
  4. temperatureunder reflux for 2 hours
  5. temperaturewas cooled
  6. filtrationfiltered
  7. customThe solids were collected
  8. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ebb6372c25844c07b7b346a7421e5219
Quelldatensatz
uspto-grants-1990_02
Patentnummer
US04902808

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