Propargyl alcohol → N-Boc-beta-alanine Propargyl Ester

HRID 12006

Reaktionsgleichung

Reaktionsgleichung von HRID 12006
[C:1]([NH:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH2:14](O)[C:15]#[CH:16].C1(N=C=NC2CCCCC2)CCCCC1>CCOC(C)=O>[CH2:16]([O:12][C:11](=[O:13])[CH2:10][CH2:9][NH:8][C:1]([O:3][C:4]([CH3:6])([CH3:7])[CH3:5])=[O:2])[C:15]#[CH:14]

Komponenten

5

Edukt 3

HCID 7859Propargyl alcoholHCID 10868DicyclohexylcarbodiimideHCID 76809N-((1,1-dimethylethoxy)carbonyl)-beta-alanine

Produkt 1

HCID 11831152N-Boc-beta-alanine Propargyl Ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

N-Boc-β-alanine (1.91 g, 10.1 mmol) and propargyl alcohol (0.675 g, 12 mmol) were dissolved in EtOAc (25 mL). Dicyclohexyl-carbodiimide (DCC, 2.06 g, 10 mmol) was added to the solution and after 16 h of stirring at room temperature, the reaction mixture was filtered and evaporated to dryness under vacuum. Crude product yield

Aufarbeitung

  1. filtrationthe reaction mixture was filtered
  2. customevaporated to dryness under vacuum
  3. customCrude product yield

Quellen und Nachweise

ORD-Eintrag
ord-71ffcbba883a4093b8e3933b35c16e12
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727713B2

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