Potassium Carbonate → 2-(4-t-Butylphenylthio)ethylamine

HRID 12015

Reaktionsgleichung

Reaktionsgleichung von HRID 12015
Cl.Cl[CH2:3][CH2:4][NH2:5].C([O-])([O-])=O.[K+].[K+].[C:12]([C:16]1[CH:21]=[CH:20][C:19]([SH:22])=[CH:18][CH:17]=1)([CH3:15])([CH3:14])[CH3:13]>C(Cl)(Cl)Cl>[C:12]([C:16]1[CH:17]=[CH:18][C:19]([S:22][CH2:3][CH2:4][NH2:5])=[CH:20][CH:21]=1)([CH3:15])([CH3:13])[CH3:14]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 754544-Tert-ButylbenzenethiolHCID 97937372-Chloroethylamine hydrochloride

Produkt 1

HCID 136820922-(4-t-Butylphenylthio)ethylamineAusbeute 74,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a stirring mixture of 4.36 g (38.0 mmol) of 2-chloroethylamine hydrochloride and 12.00 g (87.0 mmol) of K2CO3 in 30 mL of CHCl3 was added 4.82 g (29.0 mmol) of 4-t-butylbenzenethiol. The mixture was stirred at 50° C. in a sealed vial overnight. The mixture was washed three times with distilled water, dried with MgSO4 and filtered. Volatiles were removed in vacuo leaving 4.50 g (74%) of clear oil. 1H NMR (300 MHz, CDCl3): δ=7.32, m, 4H; 2.93, m, 4H; 1.42, broad singlet, 2H; 1.30, s, 9H.

Aufarbeitung

  1. washThe mixture was washed three times with distilled water
  2. dry with materialdried with MgSO4
  3. filtrationfiltered
  4. customVolatiles were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6acfba33d3264d7893baed6626e51411
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727926B2

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