1-Bromohexane → HCID 178444669, Verbindung

HRID 12062

Reaktionsgleichung

Reaktionsgleichung von HRID 12062
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[N:8]1[C:16]2[CH2:15][CH2:14][NH:13][CH2:12][C:11]=2[S:10][C:9]=1[NH:17][C:18]([NH2:20])=[NH:19].C(=O)([O-])[O-].[Cs+].[Cs+].[OH-].[Na+]>CN(C)C=O>[CH2:2]([N:13]1[CH2:14][CH2:15][C:16]2[N:8]=[C:9]([NH:17][C:18]([NH2:20])=[NH:19])[S:10][C:11]=2[CH2:12]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Komponenten

6

Edukt 4

HCID 81011-BromohexaneHCID 10796Cesium carbonateHCID 14798Sodium HydroxideHCID 178512601HCID 178512601, Verbindung

Produkt 1

HCID 178444669HCID 178444669, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

1-bromohexane (0.11 mmol) is added to a suspension of N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine (0.1 mmol) and caesium carbonate (0.22 mmol) in dimethylformamide (0.3 ml) and the reaction mixture is stirred overnight at room temperature. After adding 2M caustic soda solution (1 ml) the mixture is extracted with ethyl acetate, the combined organic phases are dried over sodium sulphate and then concentrated by evaporation, the title compound being obtained in pure form.

Aufarbeitung

  1. extractionis extracted with ethyl acetate
  2. dry with materialthe combined organic phases are dried over sodium sulphate
  3. concentrationconcentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-6b14da6e27204bad9338c2861405d99d
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727979B2

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