Cyclopropanecarboxaldehyde → 4-Trifluoromethyl-7-methyl-6-cyclopropylmethyl-6,7,8,9-tetrahydropyrido[2,3-g]quinolin-2(1H)-one

HRID 12072

Reaktionsgleichung

Reaktionsgleichung von HRID 12072
[F:1][C:2]([F:23])([F:22])[C:3]1[C:16]2[C:7](=[CH:8][C:9]3[CH2:10][CH2:11][CH:12]([CH3:20])[N:13]([CH2:17][CH2:18][CH3:19])[C:14]=3[CH:15]=2)[NH:6][C:5](=[O:21])[CH:4]=1.[CH:24]1(C=O)CC1>>[F:23][C:2]([F:1])([F:22])[C:3]1[C:16]2[C:7](=[CH:8][C:9]3[CH2:10][CH2:11][CH:12]([CH3:20])[N:13]([CH2:17][CH:18]4[CH2:24][CH2:19]4)[C:14]=3[CH:15]=2)[NH:6][C:5](=[O:21])[CH:4]=1

Komponenten

3

Edukt 2

HCID 123114CyclopropanecarboxaldehydeHCID 99670384-Trifluoromethyl-7-methyl-6-propyl-6,7,8,9-tetrahydropyrido[2,3-g]quinolin-2(1H)-one

Produkt 1

HCID 99675684-Trifluoromethyl-7-methyl-6-cyclopropylmethyl-6,7,8,9-tetrahydropyrido[2,3-g]quinolin-2(1H)-one

Versuchsvorschrift

This compound was prepared in a similar fashion as that described in Example 84 from Compound 187 (Structure 33 of Scheme VI, where R1=methyl, n=1) and cyclopropanecarboxaldehyde. 1H NMR (400 MHz, CDCl3) 10.91 (br. s, 1H), 7.14 (s, 1H), 7.01 (s, 1H), 6.94 (s, 1H), 3.65 (m, 1H), 3.35 (dd, 1H, J=15.0, 5.5), 3.09 (dd, 1H, J=15.0, 6.2), 2.97-2.82 (m, 2H), 2.00-1.94 (m, 1H), 1.84-1.79 (m, 1H), 1.17 (d, 3H, J=6.5), 0.88-0.85 (m, 1H), 0.58 (m, 2H), 0.28 (dd, 2H, J=10.3, 5.0).

Aufarbeitung

  1. customThis compound was prepared in a similar fashion as

Quellen und Nachweise

ORD-Eintrag
ord-8a9091e348c5446da72de839ee69dbae
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727980B2

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