Ethanol, 1-ethoxy-2,2,2-trifluoro- → 4-Trifluoromethyl-6-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydropyrido[2,3-g]quinolin-2(1H)-one
Reaktionsgleichung
[F:1][C:2]([F:25])([F:24])[C:3]1[C:16]2[C:7](=[CH:8][C:9]3[CH2:10][CH2:11][CH:12](C)[N:13]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:14]=3[CH:15]=2)[NH:6][C:5](=[O:23])[CH:4]=1.C(OC(O)C(F)(F)F)C>>[F:25][C:2]([F:1])([F:24])[C:3]1[C:16]2[C:7](=[CH:8][C:9]3[CH2:10][CH2:11][CH2:12][N:13]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:14]=3[CH:15]=2)[NH:6][C:5](=[O:23])[CH:4]=1Komponenten
3
Versuchsvorschrift
This compound was prepared in a similar fashion as that described in Example 84 from Compound 192 (Structure 33 of Scheme VI, where R1═H, n=1) and trifluoroacetaldehyde ethyl hemiacetal. 1H NMR (400 MHz, CDCl3) 11.32 (br. s, 1H), 7.11 (s, 1H), 7.02 (s, 1H), 6.99 (s, 1H), 3.88 (q, 2H, J=8.9), 3.47 (t, 2H, J=5.6), 2.93 (t, 2H, J=6.3), 2.03 (m, 2H).