Tetrahydrofuran → 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)-4-fluorophenyl)-3-(3-(2-fluoropropan-2-yl)isoxazol-5-yl)urea

Reaktionsgleichung

[CH2:44]1[O:45][CH2:46][CH2:47][CH2:48]1.[CH3:21][O:22][c:23]1[cH:24][c:25]2[c:26]([O:35][c:36]3[cH:37][c:38]([NH2:39])[cH:40][cH:41][c:42]3[F:43])[n:27][cH:28][n:29][c:30]2[cH:31][c:32]1[O:33][CH3:34].[F:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][o:7][c:8]([NH:10][C:11]([O:12][c:13]2[cH:14][cH:15][c:16]([Cl:17])[cH:18][cH:19]2)=[O:20])[cH:9]1>>[F:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][o:7][c:8]([NH:10][C:11](=[O:20])[NH:39][c:38]2[cH:37][c:36]([O:35][c:26]3[c:25]4[cH:24][c:23]([O:22][CH3:21])[c:32]([O:33][CH3:34])[cH:31][c:30]4[n:29][cH:28][n:27]3)[c:42]([F:43])[cH:41][cH:40]2)[cH:9]1