Acetone → 1-(3,4-Difluorophenyl)-2-methylpropan-2-ol

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Acetone	HCID 180	—
Edukt	4-(Bromomethyl)-1,2-difluorobenzene	HCID 581436	—
Produkt	1-(3,4-Difluorophenyl)-2-methylpropan-2-ol	HCID 21744463	—

Reaktionsschritte

From 23.0 g (111 mmol) of 3,4-difluorobenzyl bromide a Grignard is prepared, which is then reacted with 11.6 mL (158 mmol) of acetone. Slightly yellow oil. Yield: 9.7 g (47%); Rf value: 0.55 (ethyl acetate-petroleum ether (1:3)).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07727984B2
Quelldatensatz	uspto-grants-2010_06
ORD ID	ord-72dec086166f4873afdcae84023e3b58
Quellennotiz	uspto-grants-2010_06