Dichloromethane → 3-[2-(3-Aminopyrrolidine-1-carbonyl)-thiazolo[4,5-h]quinazolin-8-ylamino]-benzenesulfonamide

Reaktionsgleichung

[C:8]([O:9][C:10](=[O:11])[NH:14][CH:15]1[CH2:16][N:17]([C:20](=[O:21])[c:22]2[s:23][c:24]3[c:25]([cH:26][cH:27][c:28]4[cH:29][n:30][c:31]([NH:34][c:35]5[cH:36][c:37]([S:41]([NH2:42])(=[O:43])=[O:44])[cH:38][cH:39][cH:40]5)[n:32][c:33]34)[n:45]2)[CH2:18][CH2:19]1)([CH3:12])([CH3:13])[CH3:46].[Cl:47][CH2:48][Cl:49].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[NH2:14][CH:15]1[CH2:16][N:17]([C:20](=[O:21])[c:22]2[s:23][c:24]3[c:25]([cH:26][cH:27][c:28]4[cH:29][n:30][c:31]([NH:34][c:35]5[cH:36][c:37]([S:41]([NH2:42])(=[O:43])=[O:44])[cH:38][cH:39][cH:40]5)[n:32][c:33]34)[n:45]2)[CH2:18][CH2:19]1