HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Pyridine → N-(5-bromopyridin-2-yl)-2-nitrobenzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Pyridine | HCID 1049 | — |
| Edukt | 2-Nitrobenzoyl chloride | HCID 11875 | — |
| Edukt | 2-Amino-5-bromopyridine | HCID 70622 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | N-(5-bromopyridin-2-yl)-2-nitrobenzamide | HCID 679218 | 77,9% |
Reaktionsschritte
A solution of 2-nitrobenzoyl chloride (3.70 g, 20 mmol, 1.0 equiv), 2-amino-5-bromopyridine (3.50 g, 1.0 equiv), pyridine (10 mL) in 25 mL of methylene chloride was stirred overnight. The volatile was evaporated, flash chromatography on silica gel gave N-(5-bromo-2-pyridinyl)-(2-nitro)phenylcarboxamide (5.02 g, 77%). MS found for C12H9BrN3O3 (M+H)+: 322.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07727981B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-aff4bb6560f44a6c9e3a0009d8d22301 |
| Quellennotiz | uspto-grants-2010_06 |