4-Methyl-5-pyrimidinecarboxylic acid → 4-methyl-pyrimidine-5-carboxylic acid (6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-amide

HRID 12181

Reaktionsgleichung

Reaktionsgleichung von HRID 12181
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[C:13]([NH2:17])[C:14]=1[O:15][CH3:16])[NH:11][C:10]1[CH:9]=[N:8][CH:7]=[CH:6][C:5]2=1.[CH3:18][C:19]1[C:24]([C:25](O)=[O:26])=[CH:23][N:22]=[CH:21][N:20]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[C:13]([NH:17][C:25]([C:24]3[C:19]([CH3:18])=[N:20][CH:21]=[N:22][CH:23]=3)=[O:26])[C:14]=1[O:15][CH3:16])[NH:11][C:10]1[CH:9]=[N:8][CH:7]=[CH:6][C:5]2=1

Komponenten

3

Edukt 2

HCID 149222194-Methyl-5-pyrimidinecarboxylic acidHCID 213627436-Chloro-7-methoxy-9h-pyrido[3,4-b]indol-8-amine

Produkt 1

HCID 111760854-methyl-pyrimidine-5-carboxylic acid (6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-amideAusbeute 80 %

Versuchsvorschrift

The desired compound was prepared according to Method A from 6-chloro-7-methoxy-9H-beta-carbolin-8-ylamine and 4-methyl-5-pyrimidine carboxylic acid in 80% yield.

Quellen und Nachweise

ORD-Eintrag
ord-64f20c9068f249069d4f82b9cd087d27
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727985B2

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