HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 12268Erstellt: 24. Oktober 2026
1,3-Diethyl 2-oxopropanedioate → Diethyl 2-[2-(2-ethylaminopyrimidin-4-yl)-2-oxo-ethyl]-2-hydroxymalonate
https://huagongshe.com/de/reaction/12268
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 1,3-Diethyl 2-oxopropanedioate | HCID 69105 | — |
| Edukt | 1-(2-(Ethylamino)pyrimidin-4-yl)ethanone | HCID 68452125 | — |
| Produkt | Diethyl 2-[2-(2-ethylaminopyrimidin-4-yl)-2-oxo-ethyl]-2-hydroxymalonate | HCID 68452836 | — |
Reaktionsschritte
A mixture consisting of 1.9 g of 1-(2-ethylaminopyrimidin-4-yl)ethanone and 1.86 ml of diethyl ketomalonate is heated at 110° C. for 18 hours. The mixture is purified by column chromatography (silica gel, mobile phase:methylene chloride:methanol=98:2).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07727989B2 |
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| Quelldatensatz | uspto-grants-2010_06 |
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| ORD ID | ord-0d9dbd0ceb884aa9952e31fab8bb9478 |
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| Quellennotiz | uspto-grants-2010_06 |
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