1-(3-Aminopropyl)-4-methylpiperazine → 8-Cyclohexyl-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

HRID 12357

Reaktionsgleichung

Reaktionsgleichung von HRID 12357
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][NH2:11])[CH2:4][CH2:3]1.[CH2:12]([O:14][C:15]([C:17]1[C:18](=[O:37])[C:19]2[CH:24]=[N:23][C:22](S(C)(=O)=O)=[N:21][C:20]=2[N:29]([CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)[CH:30]=1)=[O:16])[CH3:13]>>[CH2:12]([O:14][C:15]([C:17]1[C:18](=[O:37])[C:19]2[CH:24]=[N:23][C:22]([NH:11][CH2:10][CH2:9][CH2:8][N:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]3)=[N:21][C:20]=2[N:29]([CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)[CH:30]=1)=[O:16])[CH3:13]

Komponenten

3

Edukt 2

HCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 252234828-Cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Produkt 1

HCID 685844928-Cyclohexyl-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Versuchsvorschrift

Using the procedure outlined in Example 28 Step F, the title compound was prepared from 3-(4-methyl-piperazin-1-yl)-propylamine and 8-cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (20 mg, 0.04 mmol). 8-Cyclohexyl-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid (17 mg, 80%). Mass Spectrum (LCMS, ESI pos.) Calcd. For C24H36N6O3: 457.28 (M+H). Found: 457.3.

Quellen und Nachweise

ORD-Eintrag
ord-37d1f52a056b469fadc08257880cf203
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728003B2

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