2-Morpholinoethylamine → 8-Cyclohexyl-5-oxo-2-(2-morpholin-4-yl-ethylamino)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Beteiligte Stoffe

Reaktionsschritte

Using the procedure outlined in Example 28 Step F, the title compound was prepared from 2-morpholin-4-yl-ethylamine and 8-cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (30 mg, 0.08 mmol). 8-Cyclohexyl-5-oxo-2-(2-morpholin-4-yl-ethylamino)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid (25 mg, 80%). Mass Spectrum (LCMS, ESI pos.) Calcd. For C22H31N5O4: 430.24 (M+H). Found: 430.2.

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