Triphenylphosphine → 4-Fluorophenethyltriphenylphosphonium bromide

HRID 12369

Reaktionsgleichung

Reaktionsgleichung von HRID 12369
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][Br:10])=[CH:4][CH:3]=1.[C:11]1([P:17]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1(C)C=CC=CC=1>[Br-:10].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][P+:17]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 11776TriphenylphosphineHCID 5731534-Fluorophenethyl bromide

Produkt 1

HCID 223867454-Fluorophenethyltriphenylphosphonium bromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
200 °C

Versuchsvorschrift

4-Fluorophenylethyl bromide (700 mg, 3.44 mmol) was dissolved in toluene (4 mL), triphenylphosphine (904 mg, 3.44 mmol) added and the solution heated for 10 min in a sealed flask at 200° C. under microwave heating. After cooling to rt, the solvent was decanted and the title compound was obtained quantitatively as the remaining glassy solid, which was used without further purification.

Aufarbeitung

  1. temperatureheating
  2. temperatureAfter cooling to rt
  3. customthe solvent was decanted

Quellen und Nachweise

ORD-Eintrag
ord-ced818104f6646a0b4c67d321a5aa17e
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727999B2

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