Isopropanol → 3-[4-(5-t-Butyl-isoxazol-3-ylamino)-pyrimidin-2-ylamino]-benzenesulfonamide

HRID 1241592Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1241592
[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13](Cl)[N:12]=2)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH2:18][C:19]1[CH:20]=[C:21]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:22]=[CH:23][CH:24]=1.CC(O)C>CS(C)=O>[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH:18][C:19]3[CH:20]=[C:21]([S:25]([NH2:28])(=[O:26])=[O:27])[CH:22]=[CH:23][CH:24]=3)[N:12]=2)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 3776IsopropanolHCID 7377Benzenesulfonamide, 3-amino-HCID 21936452(2-Chloro-pyrimidin-4-yl)-(5-tert-butyl-isoxazol-3-yl)-amine

Produkt 1

HCID 219364603-[4-(5-t-Butyl-isoxazol-3-ylamino)-pyrimidin-2-ylamino]-benzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

To a slurry of (5-t-butyl-isoxazol-3-yl)-(2-chloro-pyrimidin-4-yl)-amine (Example 2, Step A) (0.120 mg, 0.47 mmol) in DMSO (0.120 mL) was added 3-aminobenzenesulfonamide (0.082 g, 0.47 mmol). The reaction mixture was heated at 120° C. in a sealed tube for 1 h at which time TLC indicated the disappearance of starting material. IPA (5 mL) was added and the mixture was filtered and washed with IPA (2×1 mL) to yield the title compound as a white solid.

Aufarbeitung

  1. filtrationthe mixture was filtered
  2. washwashed with IPA (2×1 mL)

Quellen und Nachweise

ORD-Eintrag
ord-0553dfa72da049f8bc4ce472515ab65e
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07115617B2

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