Acetic Acid Mixture with Hydrobromic Acid → 3-(3-methylphenoxy)-N1-(2-nitrophenyl)-1,2-propanediamine hydrobromide

HRID 12417

Reaktionsgleichung

Reaktionsgleichung von HRID 12417
[CH3:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[O:5][CH2:6][CH:7]([NH:19]C(=O)OCC1C=CC=CC=1)[CH2:8][NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-:18])=[O:17].[BrH:33].C(O)(=O)C>ClCCl>[BrH:33].[CH3:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[O:5][CH2:6][CH:7]([NH2:19])[CH2:8][NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-:18])=[O:17]

Komponenten

4

Edukt 2

HCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 68698461Benzyl 2-(3-methylphenoxy)-1-[(2-nitroanilino)methyl]ethylcarbamate

Produkt 1

HCID 686969873-(3-methylphenoxy)-N1-(2-nitrophenyl)-1,2-propanediamine hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To the compound obtained in Step 2 were added 30% hydrobromide/acetic acid (1 ml) and dichloromethane (2 ml), and the mixture was stirred at 0° C. for 2 hrs. The mixture was diluted with dichloromethane, and washed with saturated aqueous sodium hydrogen carbonate. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated to give the title compound as a crude product.

Aufarbeitung

  1. washwashed with saturated aqueous sodium hydrogen carbonate
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-3d3cb8533ec6479193672c26c1ce3bd8
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728005B2

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