Sodium Bicarbonate → HCID 21937990, Verbindung

HRID 1242199

Reaktionsgleichung

Reaktionsgleichung von HRID 1242199
[C:1]1([N:7]2[C:11]3[CH:12]=[C:13]([CH3:16])[CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N+]([O-])([O-])=[O:24].[NH4+].[Ce].C(=O)(O)[O-].[Na+]>S(=O)(=O)(O)O>[C:1]1([N:7]2[C:11]3[CH:12]=[C:13]([CH:16]=[O:24])[CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 516892Sodium BicarbonateHCID 130950791,2-diphenyl-6-methyl-1H-benzimidazoleHCID 57418452Ammonium cerium-nitrate

Produkt 1

HCID 21937990HCID 21937990, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

1 g of 1,2-diphenyl-6-methyl-1H-benzimidazole was suspended in 31 ml of 40% sulfuric acid and mixed with 13.5 g of cerium ammonium nitrate. It was allowed to stir for 2.5 hours at 80° C., cooled to 20° C., and carefully stirred into saturated aqueous sodium bicarbonate solution. The mixture was extracted three times with ethyl acetate, the combined extracts were washed with saturated aqueous sodium chloride solution, dried on sodium sulfate solution and evaporated to the dry state in a vacuum. The residue was chromatographed on silica gel.

Aufarbeitung

  1. temperaturecooled to 20° C.
  2. extractionThe mixture was extracted three times with ethyl acetate
  3. washthe combined extracts were washed with saturated aqueous sodium chloride solution
  4. customdried on sodium sulfate solution
  5. customevaporated to the dry state in a vacuum
  6. customThe residue was chromatographed on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-03cdcc07b1714843a97866c92fc75c34
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07115645B2

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