Reaktionsgleichung
[CH3:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.[C:19]([O:23][C:24](=[O:39])[C:25]([O:28][C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([CH2:35][C:36](O)=[O:37])[CH:30]=1)([CH3:27])[CH3:26])([CH3:22])([CH3:21])[CH3:20].COC(=O)CC1C=CC=C(O)C=1.BrC(C)(C)C(OC(C)(C)C)=O>>[C:19]([O:23][C:24](=[O:39])[C:25]([CH3:26])([O:28][C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([CH2:35][C:36](=[O:37])[NH:8][C:7]2[C:2]([CH3:1])=[N:3][C:4]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:16])([F:18])[F:17])=[CH:11][CH:10]=3)=[CH:5][CH:6]=2)[CH:30]=1)[CH3:27])([CH3:21])([CH3:20])[CH3:22]Komponenten
5
Edukt 4
Produkt 1
Versuchsvorschrift
In analogy to the procedures described in example 26B] and 124C], 2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylamine (example 125C]) was reacted with 2-(3-carboxymethyl-phenoxy)-2-methyl-propionic acid tert-butyl ester (prepared from (3-hydroxy-phenyl)-acetic acid methyl ester and tert-butyl alpha-bromoisobutyrate, in analogy to the procedure described in example 52A], followed by saponification in analogy the procedure described in example 124A]) to give 2-methyl-2-(3-{[2-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylcarbamoyl]-methyl}-phenoxy)-propionic acid tert-butyl ester, which was subsequently cleaved with trifluoroacetic acid to yield the title compound as light yellow amorphous solid.
Quellen und Nachweise
- ORD-Eintrag
- ord-11bb8b44725045a4b42af22100163a60
- Quelldatensatz
- uspto-grants-2006_10
- Patentnummer
- US07115611B2
Verknüpfte Notizen
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