Diisobutylaluminum hydride → 3-Phenylpropane-1,2-diamine

A solution of 2 (18.25 g, 0.125 mol) in dichloromethane (150 mL) was added over 30 min to a 1M solution diisobutylaluminum hydride of DIBAL (500 mL, 0.5 mol) cooled to −10°. The temperature raised to −5° and returned to −10°. The starting material was gone after 15 min (GC). The cooled reaction mixture was treated with 500 mL of aqueous 2N sodium hydroxide at a rate, which kept the temperature under 20°. The resulting mixture was stirred at room temperature for 1 hr and then it was filtered through 1PS filter paper. The solvent was evaporated under reduced pressure and the residue was distilled through a short path column to give 12.7 g (68% yield) of 3-phenyl-1,2-diamino-propane, 3 (b.p. 78–83° C., 0.2–0.3 mm) which was 90% pure by glpc. NMR (CDCl3) δ 7.4 (s, 5H), 2.4–3.2 (m, 5H), 1.4 (s, 4H).

1. temperaturecooled to −10°
2. temperatureThe temperature raised to −5°
3. customreturned to −10°
4. customThe cooled reaction mixture
5. customunder 20°
6. filtrationit was filtered through 1PS filter paper
7. customThe solvent was evaporated under reduced pressure
8. distillationthe residue was distilled through a short path column

ORD-Eintrag

ord-a210e8e7ca3f4defb574a7aff118a702

Quelldatensatz

uspto-grants-2006_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07115748B2