Hydrochloric Acid → HCID 4590482, Verbindung

HRID 1242895Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1242895
[OH-].[Na+].[C:3]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:8]=[CH:7][C:6]([C:9]([NH:11][C:12]2[CH:21]=[CH:20][C:15]([C:16]([O:18]C)=[O:17])=[CH:14][CH:13]=2)=[O:10])=[CH:5][CH:4]=1.Cl.C(OCC)(=O)C>C1COCC1.CO>[C:3]1([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:8]=[CH:7][C:6]([C:9]([NH:11][C:12]2[CH:21]=[CH:20][C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=2)=[O:10])=[CH:5][CH:4]=1

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 2838376HCID 2838376, Verbindung

Produkt 1

HCID 4590482HCID 4590482, VerbindungAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

1N Aqueous sodium hydroxide solution (8 ml) was added to a mixed solution of methyl 4-(4-biphenylylcarbonylamino)benzoate (1.998 g) in THF (60 ml) and methanol (20 ml), which was stirred at room temperature for 18 hours. 1N Hydrochloric acid (10 ml) was added to the reaction mixture, and extraction was conducted using ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride solution, dried, and then concentrated. The resulting crude crystals were washed with diethyl ether to give the titled compound (1.760 g).

Aufarbeitung

  1. washThe organic layer was washed with water and saturated aqueous sodium chloride solution
  2. customdried
  3. concentrationconcentrated
  4. washThe resulting crude crystals were washed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-aa7b9baf24e846868f71db62b820a5e6
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07115750B1

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