Dimethylformamide → Methyl 8-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

HRID 1243144Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1243144
[CH3:1]N(C=O)C.[CH3:6][O:7][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:17]=1[CH2:16][CH:15]([C:18]([OH:20])=[O:19])[CH2:14][CH2:13]2.CI.C([O-])([O-])=O.[K+].[K+]>C(OCC)(=O)C>[CH3:1][O:19][C:18]([CH:15]1[CH2:14][CH2:13][C:12]2[C:17](=[C:8]([O:7][CH3:6])[CH:9]=[CH:10][CH:11]=2)[CH2:16]1)=[O:20]

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 36247098-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic Acid

Produkt 1

HCID 13058286Methyl 8-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a DMF solution (30 mL) of 8-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid (5.0 g, 24 mmol) was added MeI (7.1 g, 50 mmol) and K2CO3 (6.9 g, 50 mmol). The mixture was allowed to stir overnight and ethyl acetate (200 mL) was added. The resulting solution was washed with water (3×50 mL) and brine (50 mL) to provide 8-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid methyl ester (6.6 g).

Aufarbeitung

  1. washThe resulting solution was washed with water (3×50 mL) and brine (50 mL)

Quellen und Nachweise

ORD-Eintrag
ord-3ff1f3a69cb44de592296d9aced13302
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07115767B2

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