Hydrochloric Acid → HCID 21928083, Verbindung
Reaktionsgleichung
C(OC(=O)[NH:7][CH2:8][CH:9]([C:11]1[CH:16]=[CH:15][C:14]([C:17](=[O:26])[NH:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:13][N:12]=1)[OH:10])(C)(C)C.[ClH:28].O1CCOCC1>CCOC(C)=O>[ClH:28].[ClH:28].[NH2:7][CH2:8][CH:9]([C:11]1[CH:16]=[CH:15][C:14]([C:17]([NH:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:26])=[CH:13][N:12]=1)[OH:10]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
[2-(5-Benzylcarbamoyl-pyridin-2-yl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester (47.0 mg, 0.129 mmol) was dissolved into 2 mL of EtOAc and 4.0 N HCl in dioxane (1.0 mL, 4 mmol) was added. The reaction was allowed to stir overnight. The resulting precipitate was triturated with 3×5 mL of THF and concentrated on a rotary evaporator to dryness to give 43 mg of 6-(2-amino-1-hydroxy-ethyl)-N-benzyl-nicotinamide 2HCl.