Hydrochloric Acid → (2,4-Dimethyl-phenyl)-(4-fluoro-phenyl)-methanone

HRID 1243911

Reaktionsgleichung

Reaktionsgleichung von HRID 1243911
[Cl-].[Al+3].[Cl-].[Cl-].[F:5][C:6]1[CH:14]=[CH:13][C:9]([C:10](Cl)=[O:11])=[CH:8][CH:7]=1.Cl.[C:16]1([CH3:23])[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[CH:17]=1>>[CH3:23][C:16]1[CH:21]=[CH:20][C:19]([C:10](=[O:11])[C:9]2[CH:13]=[CH:14][C:6]([F:5])=[CH:7][CH:8]=2)=[C:18]([CH3:22])[CH:17]=1

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 7929M-XyleneHCID 678794-Fluorobenzoyl chlorideHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 10242880(2,4-Dimethyl-phenyl)-(4-fluoro-phenyl)-methanoneAusbeute 99 %

Versuchsvorschrift

To a suspension of anhydrous aluminum chloride (19.5 g) dispersed in m-xylene (150 ml) was added dropwise 4-fluorobenzoyl chloride (21.1 g) under ice-cooling. The mixture was stirred at 0–10° C. for 3 hr and poured into 6N hydrochloric acid. The reaction mixture was partitioned and the obtained organic layer was washed successively with water, 10% aqueous sodium hydroxide solution and water. The solvent was evaporated to give a 96:4 mixture (30.2 g, 99%) of 1,3-dimethyl-4-(4′-fluorobenzoyl)benzene and 1,3-dimethyl-2-(4,-fluorobenzoyl)benzene as pale-yellow oil. 1,3-Dimethyl-4-(4′-fluorobenzoyl)benzene

Aufarbeitung

  1. temperaturecooling
  2. customThe reaction mixture was partitioned
  3. washthe obtained organic layer was washed successively with water, 10% aqueous sodium hydroxide solution and water
  4. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-e8a9d9c492ee47ee9e33814d1eba010b
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07119215B2

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