6-Methyl-2-phenylpiperidin-3-amine → 6-Methoxy-3-methyl-5-[(6-methyl-2-phenyl-piperidin-3-ylamino)-methyl]-1,1a,3,7b-tetrahydro-3-aza-cyclopropa[a]naphthalen-2-one

HRID 1244070Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1244070
[CH3:1][CH:2]1[NH:7][CH:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]([NH2:14])[CH2:4][CH2:3]1.C[C@H]1N[C@H](C2C=CC=CC=2)[C@H](N)CC1.[CH3:29][O:30][C:31]1[CH:40]=[C:39]2[C:34]([N:35]([CH3:43])[C:36](=[O:42])[CH:37]3[CH2:41][CH:38]32)=[CH:33][C:32]=1[CH:44]=O>>[CH3:29][O:30][C:31]1[CH:40]=[C:39]2[C:34]([N:35]([CH3:43])[C:36](=[O:42])[CH:37]3[CH2:41][CH:38]32)=[CH:33][C:32]=1[CH2:44][NH:14][CH:5]1[CH2:4][CH2:3][CH:2]([CH3:1])[NH:7][CH:6]1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

4

Edukt 3

HCID 98775926-Methyl-2-phenylpiperidin-3-amineHCID 99646446-Methoxy-3-methyl-2-oxo-1a,2,3,7b-tetrahydro-1H-3-aza-cyclopropa[a]naphthalene-5-carbaldehydeHCID 69654587HCID 69654587, Verbindung

Produkt 1

HCID 219316576-Methoxy-3-methyl-5-[(6-methyl-2-phenyl-piperidin-3-ylamino)-methyl]-1,1a,3,7b-tetrahydro-3-aza-cyclopropa[a]naphthalen-2-one

Versuchsvorschrift

By a procedure similar to the previous examples 9 and 9A: prepared through the reaction of 6-Methyl-2-phenyl-piperidin-3-ylamine [or (2S,3S,6S,)-6-methyl-2-phenyl-piperidin-3-ylamine or (2R,3R,6R)-6-methyl-2-phenyl-piperidin-3-ylamine] with 6-Methoxy-3-methyl-2-oxo-1a,2,3,7b-tetrahydro-1H-3-aza-cyclopropa[a]naphthalene-5-carbaldehyde [or (1S,1aR)-6-Methoxy-3-methyl-2-oxo-1a,2,3,7b-tetrahydro-1H-3-aza-cyclopropa[a]naphthalene-5-carbaldehyde or (1R, 1aS)-6-Methoxy-3-methyl-2-oxo-1a,2,3,7b-tetrahydro-1H-3-aza-cyclopropa[a]naphthalene-5-carbaldehyde].

Quellen und Nachweise

ORD-Eintrag
ord-19d6f056f7084804ad5317e5a934d7ca
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07119207B2

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