Trifluoroacetic acid → 1,1-Dimethyl-4-nitro-butylamine trifluoroacetate

HRID 1244080Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1244080
C(OC(=O)[NH:7][C:8]([CH3:16])([CH3:15])[CH2:9][CH2:10][CH2:11][N+:12]([O-:14])=[O:13])(C)(C)C.[C:18]([OH:24])([C:20]([F:23])([F:22])[F:21])=[O:19]>C(Cl)Cl>[F:21][C:20]([F:23])([F:22])[C:18]([OH:24])=[O:19].[CH3:15][C:8]([NH2:7])([CH3:16])[CH2:9][CH2:10][CH2:11][N+:12]([O-:14])=[O:13]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86587889HCID 86587889, Verbindung

Produkt 1

HCID 219316631,1-Dimethyl-4-nitro-butylamine trifluoroacetateAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To (1,1-Dimethyl-4-nitro-butyl)-carbamic acid tert-butyl ester (1.0 g, 4.0 mmol) in 25 mL CH2Cl2 at −10° C. was added 2.5 mL TFA. The mixture was warmed to rt and monitored by TLC. When judged complete by TLC analysis, the mixture was concentrated to give the 518 mg (88%) of the title compound as an orange oil: mass spectrum m/e=147 (M+1).

Aufarbeitung

  1. concentrationthe mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-cf4b506976344b1b80f8586c74ed6fea
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07119207B2

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