Dextrorphan hydrobromide → Dextrorphan

HRID 1244213Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1244213
[CH3:1][N:2]1[C@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]=3[C@:5]3([C@@H:10]2[CH2:9][CH2:8][CH2:7][CH2:6]3)[CH2:4][CH2:3]1.Br>C(#N)C.[N+]([O-])([O-])=O.[Ag+]>[CH3:1][N:2]1[C@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]=3[C@:5]3([C@@H:10]2[CH2:9][CH2:8][CH2:7][CH2:6]3)[CH2:4][CH2:3]1

Komponenten

4

Edukt 1

HCID 12309240Dextrorphan hydrobromide

Produkt 1

HCID 5360697Dextrorphan

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 24470Silver NitrateKatalysatorHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

The salt is prepared by adding silver nitrate (0.50 g, 2.96 mmoles) to a solution of Dextrorphan hydrobromide (1 g, 2.96 mmoles) in acetonitrile (17 ml). The solution is then stirred at room temperature for 30 minutes. Filtering is then effected to remove silver bromide precipitate. The clear solution is added of ethyl ether (100 ml). A precipitate is formed, that is filtered, washed with ethyl ether and dried under vacuum. The solid obtained at the elemental analysis corresponds to the nitrate salt of Dextrorphan:

Aufarbeitung

  1. customThe salt is prepared
  2. filtrationFiltering
  3. customto remove silver bromide precipitate
  4. additionThe clear solution is added of ethyl ether (100 ml)
  5. customA precipitate is formed
  6. filtrationthat is filtered
  7. washwashed with ethyl ether
  8. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ceea208177d7411a81d584ecab9228dd
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07122539B2

Notizen zur Reaktion

Wird geladen…