Diethylamine → HCID 85961308, Verbindung

HRID 1244256

Reaktionsgleichung

Reaktionsgleichung von HRID 1244256
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].[CH2:6]([O:8][C:9]([C:11]1[N:12]=[N:13][C:14]([Cl:18])=[CH:15][C:16]=1Cl)=[O:10])[CH3:7]>C(OCC)(=O)C>[CH2:6]([O:8][C:9]([C:11]1[N:12]=[N:13][C:14]([Cl:18])=[CH:15][C:16]=1[N:3]([CH2:4][CH3:5])[CH2:1][CH3:2])=[O:10])[CH3:7]

Komponenten

4

Edukt 2

HCID 8021DiethylamineHCID 53428795Ethyl 4,6-dichloropyridazine-3-carboxylate

Produkt 1

HCID 85961308HCID 85961308, VerbindungAusbeute 98,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Diethylamine (86 mg, 1.3 equivalents, 1.2 mmol) is added to a solution of 4,6-dichloro-pyridazine-3-carboxylic acid ethyl ester (0.2 g, 0.91 mmol) in ethyl acetate (10 mL) at room temperature. After overnight stirring, the reaction is quenched with water (6 mL). The organic layer is separated and the aqueous layer extracted (2×15 mL) with ethyl acetate. The combined organic layers are dried and solvent removed to give 230 mg of 6-chloro-4-diethylamino-pyridazine-3-carboxylic acid ethyl ester as a yellowish oil.

Aufarbeitung

  1. customthe reaction is quenched with water (6 mL)
  2. customThe organic layer is separated
  3. extractionthe aqueous layer extracted (2×15 mL) with ethyl acetate
  4. customThe combined organic layers are dried
  5. customsolvent removed

Quellen und Nachweise

ORD-Eintrag
ord-9e8b97256656485b83fc086a99a545bc
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07122546B2

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