Sulfuric Acid → HCID 10336428, Verbindung

HRID 1244548Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1244548
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:19](=[O:20])[CH2:18][CH:17]([C:21]([OH:23])=[O:22])[CH2:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.Cl[CH2:30]Cl>CO>[CH3:30][O:22][C:21]([CH:17]1[CH2:18][C:19](=[O:20])[N:15]([C:12]2[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:10][CH:11]=2)[CH2:16]1)=[O:23]

Komponenten

5

Edukt 3

HCID 1118Sulfuric AcidHCID 6344DichloromethaneHCID 2968114STK087815

Produkt 1

HCID 10336428HCID 10336428, VerbindungAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

7.46 g (24 mmol) (RS)-1-(4-benzyloxy-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid is dissolved in a mixture of 40 ml dichloromethane and 7.5 ml methanol. 0.13 ml concentrated sulfuric acid is added and the reaction mixture hold under reflux over night. The solvent is evaporated and the residue triturated with diethyl ether to yield 7.26 g (93%) of a colorless solid (used in the next step without further purification).

Aufarbeitung

  1. temperaturethe reaction mixture hold under reflux over night
  2. customThe solvent is evaporated
  3. customthe residue triturated with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-5dcaa54585db449f9338e0b2d36fc772
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07122562B2

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