Potassium Carbonate → HCID 68614531, Verbindung
Reaktionsgleichung
[CH3:1][O:2][C:3]([CH:5]1[CH2:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17]O)=[CH:13][CH:12]=2)[CH2:6]1)=[O:4].[F:19][C:20]1[CH:27]=[CH:26][C:23]([CH2:24]Br)=[CH:22][CH:21]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:1][O:2][C:3]([CH:5]1[CH2:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:24][C:23]3[CH:26]=[CH:27][C:20]([F:19])=[CH:21][CH:22]=3)=[CH:13][CH:12]=2)[CH2:6]1)=[O:4]Komponenten
4
Versuchsvorschrift
In an analogous manner to that described in Example 1d), the alkylation of the (RS)-1-(4-hydroxyoxy-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester with 4-fluorobenzylbromide in presence of potassium carbonate yields the (RS)-1-[4-(4-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester as a light yellow powder; MS: m/e=344 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag